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October 19, 2012
The V Foundation’s Scientific Advisory Board members presented the most recent cancer breakthroughs and a progress report on V Foundation-funded cancer research.
The V Foundation has awarded over $115 million in 500+ grants to fund breakthroughs in cancer research. The medical doctors and scientists presenting at the Research Symposium are, without a doubt, the absolute experts in their field, and the V Foundation is thankful for, and honored by, their presence and continuing contributions.
Dr. Robert Bast, chairman of the Foundation’s Scientific Advisory Board, opened the symposium, which was attended by over 200 people, by announcing the Board’s renewed focus on Translational Clinical Research to facilitate the transition of research projects from the laboratory to the clinic. Translational researchers seek to apply basic knowledge of cancer and bring the benefits of the new basic-level understandings to patients more quickly and efficiently. Dr. Bast is Vice President for Translational Research at MD Anderson Cancer Center in Houston. He is also a founding member of The V Foundation Board of Directors and the Scientific Advisory Board.
Dr. Bast described the three kinds of Research Grants that The V Foundation provides:
Dr. Bast then described the results of a V Foundation Translational Grant that was made to find cures for melanoma, a very common skin cancer. Through specialized research that provided deeper understanding about the cells and molecules affected by this cancer, success was measured in 50% of the patients who have had abnormal DNA from a single gene. By combining targeted therapies with new immunotherapies, there has been an 80% success rate and the skin cancer has not returned. There is more research to be done, but the progress in combating melanoma is continuous.
Dr. Bast then introduced Sylvia Plevritis, PhD., Associate Professor, Department of Radiology at Stanford University School of Medicine. Dr. Plevritis, a very senior research professional who has already received multiple grants from the National Institute of Health, described her work in breast cancer computer modeling. She received a Translational Grant from The V Foundation to study genomic therapies and the value of early screening and detection of breast cancer. She and her team have created an on-line Decision Support Tool which is publically available at http://brcatool.stanford.edu/ . This decision support tool is designed for joint use by women with BRCA gene mutations and their health care providers. The goal of this tool is to inform discussion between providers and patients about options for reducing cancer risk. Dr Plevritis also discussed her Systems Biology Research, which is based on a “tsunami of molecular data” available in the public domain, from all of the cancer research that has been carried out, and the challenge of integrating and synthesizing this complex data to inform better outcomes. The specific purpose is: 1) to identify cellular networks of cancer and the drivers of initiation and progression, 2) to identify potential therapeutic targets and mechanisms of action, 3) to identify prognostic and predictive biomarkers, with the ultimate goal of accelerating benefits from the laboratory bench to the patient’s bedside.
Dr Bast then opened the Cancer Symposium to Q & A, after first introducing the entire V Foundation Scientific Advisory Board who were in attendance, to provide specific answers to questions from the attendees. A summary of the discussion is below (see the YouTube videos for the complete discussion):
To view the Cancer Research Symposium in its entirety, visit the V Foundation Wine Celebration’s YouTube channel: http://www.youtube.com/winecelebration. The V Foundation works with the best and brightest scientists and doctors to fight cancer. Their goal is to use all of the cancer fighting therapies, in combination, to create a personal therapy to respond to the unique cancers that exist.
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NAPA VALLEY, CA, AUGUST 9, 2016 – The V Foundation for Cancer Research’s annual fundraiser, the V Wine Celebration, garnered